Goals / Weight & metabolism

Goal guide

Weight & metabolism

This is where peptide research is strongest. Several peptides in this group are FDA-approved medicines backed by large human trials. Others are still investigational.

Foundations first

No peptide replaces these. They drive most of the results.

Protein-forward mealsStrength training to protect muscleConsistent sleepRegular bloodwork with a provider

Peptides researched for weight & metabolism

Ranked from strongest to earliest-stage evidence.

GLP-1 receptor agonist

Semaglutide

A GLP-1 receptor agonist and one of the most studied peptide medicines in the world.

FDA-approved drugDual GIP / GLP-1 receptor agonist

Tirzepatide

The first approved medicine that activates both the GIP and GLP-1 receptors.

FDA-approved drugGHRH analog

Tesamorelin

A growth-hormone-releasing hormone analog with a narrow FDA approval.

FDA-approved drugTriple GIP / GLP-1 / glucagon receptor agonist

Retatrutide

An investigational "triple agonist" currently in late-stage clinical trials.

Human clinical trialsLong-acting amylin analog

Cagrilintide

An amylin analog being studied alone and in combination with semaglutide.

Human clinical trialsModified growth hormone fragment

AOD-9604

A fragment of growth hormone once developed as an obesity drug.

Human clinical trialsMitochondrial-derived peptide

MOTS-c

A peptide encoded in mitochondrial DNA, studied for its role in metabolism.

Mostly animal research

Educational content, not medical advice. Talk to a licensed provider before starting anything.