Evidence

How we grade evidence

Every peptide in the library gets one of four levels. Here's what each one means.

FDA-approved drug

FDA-approved drug

Approved by the FDA for specific uses, backed by large human clinical trials. Prescription only.

In the library: Semaglutide, Tirzepatide, Tesamorelin, PT-141

Human clinical trials

Human clinical trials

Studied in controlled human trials, but not FDA-approved for the uses people commonly discuss.

In the library: Retatrutide, Cagrilintide, Sermorelin, Thymosin Alpha-1, AOD-9604

Early human research

Early human research

Small or early-stage human studies. Promising signals, far from settled.

In the library: CJC-1295, Ipamorelin, GHK-Cu, Selank, Semax, Kisspeptin

Mostly animal research

Mostly animal research

Most published evidence comes from cell and animal studies. Human data is limited or absent.

In the library: BPC-157, TB-500, Epitalon, MOTS-c

Why animal research isn't enough

Animal studies are where most medicines start, and they're valuable. But many results in rodents never carry over to people, and side effects that matter in humans can be missed. Until a peptide is tested in well-designed human trials, its safety and effectiveness in people are unknown.

Where our sources come from

We base entries on published research and public regulatory information. Each peptide page links to its research on PubMed, the U.S. National Library of Medicine database, so you can check it yourself.